生命第一个月的结构功能合:与年龄和注意力相关联
Ursula A Tooley1, Jeanette K Kenley2, M Catalina Camacho1
1Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110.
概括
大脑结构和功能合在婴儿皮层中各不相同. 早期合预测了以后的注意力技能,突出了关键的早期大脑发育时期.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 了解大脑结构和功能之间的关系在神经科学中至关重要.
- 早期生命中结构性和功能性大脑连接的发展尚未完全理解.
研究的目的:
- 描述健康新生儿结构功能合的区域差异.
- 调查结构功能合与生命第一个月的年龄之间的关联.
- 探索早期结构-功能合如何预测以后的认知能力,特别是视觉空间注意力.
主要方法:
- 利用神经成像技术评估239名健康新生儿的大脑结构和功能.
- 通过将皮质结构连接与神经活动模式联系起来来量化结构-功能合.
- 分析了与年龄相关的合变化及其与功能和白质连接模式的关联.
主要成果:
- 结构-功能合在皮层中呈现异质模式,在听觉,侧面前额和下额头区域的合更高.
- 在第一个月,平均结构-功能合与年龄相比下降,特别是在听觉和体力运动区域.
- 出生时特定大脑系统中较高的结构-功能合预测到一岁时视觉空间注意力发展更快.
结论:
- 早期的大脑发育显示了结构-功能合的显著区域差异.
- 与年龄相关的结构和功能脱发生在生命的第一个月内,与连接模式的转变有关.
- 新生儿结构-功能合是以后注意力发展的潜在预测因素,为关键的发展轨迹提供了洞察力.
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