生物分子凝聚物的物质特性来自纳米级动力学
Nicola Galvanetto1,2, Miloš T Ivanović1, Simone A Del Grosso1
1Department of Biochemistry, University of Zurich, Zurich 8057, Switzerland.
概括
生物分子凝聚物粘度与分子动力学有关. 聚合物物理学准确地预测了来自蛋白质扩散和链动态的凝结物质特性,揭示了聚电解质区的一般机制.
科学领域:
- 生物物理学的生物物理.
- 聚合物物理 聚合物物理
- 细胞生物学 细胞生物学
背景情况:
- 由相分离形成的生物分子凝聚物对于细胞功能至关重要.
- 它们的粘弹性特性有很大差异,但与纳米级分子动态的联系尚不清楚.
研究的目的:
- 研究纳米级动力学与生物分子凝聚物的散装粘度之间的关系.
- 确定分子级别的特性如何决定凝结物的宏观物理特征.
主要方法:
- 研究了由充电无序蛋白质和多的复杂协形成的凝聚物.
- 利用聚合物物理关系将粘度与蛋白质扩散和链动力学相关联.
- 采用原子模拟来分析残留间接触动态和摩擦.
主要成果:
- 凝聚物粘度与蛋白质转化扩散和纳米至微秒链动态有很强的相关性.
- 分析性聚合物物理模型成功地从动力学中预测粘度,反之亦然.
- 间残留接触寿命受氨酸含量和盐度的影响,解释了动态差异.
结论:
- 在多种多电解质系统中,纳米级动力学和宏观粘度之间存在机械联系.
- 间残留接触的快速交换可以防止在拥挤的多电解质环境中 (如细胞核) 发生动态停止.
相关概念视频
02:35Noncovalent Attractions in Biomolecules
55.8K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
55.8K
02:58Chemistry of the Cell
44.3K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
44.3K