从病理生理学上相关的双S暴露通过破坏棕色脂肪组织调节的能量代谢来加速衰老
1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
概括
双S (BPS) 是一种常见的BPA替代品,在相关暴露水平下加速和老鼠的衰老. 这种衰老效应与棕色脂肪组织 (BAT) 中的BPS积累和功能障碍有关.
科学领域:
- 环境健康 环境健康
- 衰老研究研究 衰老研究
- 毒理学 毒理学 毒理学
背景情况:
- 双A (BPA) 替代品在消费品和与食品接触的材料中普遍存在.
- 从病理生理学上相关的BPA替代品度对衰老的影响尚不清楚.
- 双S (BPS) 是一个广泛使用的BPA替代品.
研究的目的:
- 为了研究五种BPA替代品对衰老的影响,使用*Caenorhabditis elegans* (*C. elegans*) 和小鼠模型.
- 检查BPA替代品诱导衰老的潜在机制,重点关注双S (BPS).
主要方法:
- 暴露C. elegans和小鼠在五种BPA替代品的病理生理学相关度下.
- 对暴露生物体的衰老表型,寿命和健康寿命的评估.
- 分析小鼠组织中BPS积累的情况,特别是棕色脂肪组织 (BAT).
- 最佳技术的RNA测序,以确定受BPS影响的衰老途径.
- 在小鼠中进行了BAT移植实验,以评估BAT在BPS诱导的衰老中的作用.
主要成果:
- 暴露于相关度的双S (BPS) 加快了C. elegans*的衰老.
- 在小鼠中,BPS暴露减少了寿命和健康期,并加速了多种组织中的衰老表型.
- BPS在棕色脂肪组织 (BAT) 中大量积累,并通过多种途径加速其衰老.
- BAT移植证实了其作用:BPS暴露的BAT加速了接受者的衰老,而未暴露的BAT改善了暴露的小鼠的代谢状态和延迟衰老.
结论:
- 从病理生理学上相关的双S (BPS) 度在C. elegans和小鼠中加速衰老.
- BPS的衰老效应显著通过色脂肪组织 (BAT) 功能中断的中介.
- 这些发现凸显了与BPS暴露相关的潜在健康风险,特别是与衰老有关.
相关概念视频
01:26Aging
198
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
198
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:19Pigmentation
2.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.8K
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K