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皮拉功能化生物MOF用于水溶液中素和酸的选择性发光传感

Fei-Long Luo¹, Hao-Bo Wang¹, Kun Wu¹

¹College of Chemistry and Materials Science, and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry, Jinan University, Guangzhou, Guangdong 510632, P. R. China.

Inorganic chemistry

|June 2, 2025

概括

我们使用混合链接器方法开发了稳定的生物金属有机框架 (Bio-MOFs). 这些生物MOF显示了用于敏感抗生素检测的增强发光,使实时监控成为可能.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
分析化学分析化学

背景情况:

生物金属有机框架 (Bio-MOFs) 由于其可调节的结构,为传感应用提供了潜力.
现有的生物MOF可能缺乏足够的稳定性或灵敏性,无法进行实际的环境和生物监测.

研究的目的:

为抗生素检测合成新型,稳定和高度敏感的生物MOF.
研究链接器修改对生物MOFs发光特性和传感能力的影响.
开发一个实用的传感平台,实时进行现场抗生素监测.

主要方法:

使用混合链接器策略合成异构阳离子微孔生物MOFs.
在水溶液中在广泛的pH范围 (3-14) 中评估化学稳定性.
发光量定位研究,以评估能量传输效率和链接效应.
混合矩阵膜的制造,用于实时传感应用.

主要成果:

合成的生物MOF在水性介质中表现出极好的化学稳定性.
在链接器中用pyrazine替换核可通过改进的能量传输显著增强发光.
设计的Bio-MOF在检测胆固醇 (COL) 和酸 (NFZ) 方面表现出卓越的性能,其检测极限低 (1.5μM为COL,0.8μM为NFZ).
在存在潜在干扰物的情况下,可以选择性地检测到COL和NFZ.
一个混合矩阵膜使得实时,现场监测的COL和NFZ.

结论:

混合链接器策略和链接器工程对于开发强大而敏感的生物MOFs是有效的.
经过皮拉修改的Bio-MOF在选择性和敏感的抗生素检测方面显示出显著的前景.
开发的混合矩阵膜平台可方便实用的实时现场监测抗生素.

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