2型糖尿病的持续时间和空气运动干预后的虹膜素反应:INTENSITY研究的结果
Amy M Thomson1,2, Yadab Paudel1,2, Brittany V Rioux1,2
1Cardiometabolic Exercise & Lifestyle Laboratory, University of New Brunswick, Fredericton, NB, Canada.
概括
根据疾病持续时间,有氧运动对2型糖尿病 (T2DM) 患者的虹膜素水平有不同的影响. 长时间的T2DM患者在高强度运动时呈现出增加的虹膜蛋白,与短时间患者不同.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 代谢疾病 代谢疾病
背景情况:
- 虹膜素是一种脂肌基因,与心肺健康和2型糖尿病 (T2DM) 有关.
- 运动对不同疾病持续时间的T2DM患者的虹膜素水平的影响尚不清楚.
研究的目的:
- 为了研究28周的中度至强度有氧运动对血虹膜素水平的影响.
- 为了比较短期T2DM (<10年) 和长期T2DM (≥10年) 个体之间的这些影响.
主要方法:
- 一项涉及34名T2DM参与者的INTENSITY研究的二次分析.
- 参与者进行了28周的有氧运动,随机选择了12周的持续或增加强度.
- 使用ELISA和西部涂抹在基线,16周和28周测量了血虹膜素水平.
主要成果:
- 观察到一个显著的时间 × T2DM 持续时间组相互作用.
- 西部斑点分析显示,长期T2DM组的血虹膜素增加1.37倍,运动强度增加 (p=0.03).
- 在维持强度组中,无论是短期还是长期的T2DM,都没有发现虹膜素表达的显著变化.
结论:
- 28周的中度至强度有氧运动对短期和长期T2DM患者的血虹膜素水平有不同的影响.
- 运动强度可能在调节长期T2DM中的虹膜素反应中发挥作用.
相关概念视频
Carbohydrate Metabolism
11.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.8K
Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Insulin: Dosing Regimen and Adverse Effects
271
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
271
Diabetes Mellitus: Overview and Type I Subtype
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K
Diabetes: Symptoms, Diagnosis, and Complications
715
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
715
Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K


