基托桑海绵添加了高产量的微孔碳纳米圈,用于快速静血
Youjing Shi1, Lijie Wang1, Wei Wei1
1Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
International journal of biological macromolecules
|June 2, 2025
概括
一种装有碳纳米球 (PC-800) 的新型酸盐海绵提供快速有效的血静. 这种绿色,低成本的材料显示了作为紧急出血控制的安全和快速包裹的承诺.
科学领域:
- 生物材料科学 生物材料科学
- 血液静止研究 血液静止研究
- 纳米技术应用 纳米技术应用
背景情况:
- 快速静血对于控制血液流失和预防创伤中致命并发症至关重要.
- 现有的静血剂需要在速度,有效性和安全性方面进行改进.
- 素和碳纳米结构以其静血潜力而闻名.
研究的目的:
- 开发和描述一种装有微孔碳纳米球 (PC-800) 的新型酸盐海绵,用于快速静血.
- 为了研究基托和PC-800的协同血静效应.
- 评估这种复合海绵在创伤治疗中的可行性.
主要方法:
- 微孔碳纳米圈 (PC-800) 通过水热方法和化合成.
- PC-800均分散在酸盐溶液中,然后进行冷化,形成复合海绵.
- 评估海绵结构,机械性能,吸水能力,血红相容性和细胞毒性.
- 在老鼠模型中的体内血静评估 (尾巴和肝脏出血).
主要成果:
- 复合海绵具有多孔结构,具有合适的机械性能和高吸水率 (49.2 g/g).
- 观察到良好的血液相容性 (血解率<5%) 和低细胞毒性,尽管过度使用PC-800会增加细胞毒性.
- 与Celox Rapid相比,CS-1.0复合海绵显著增强了血液凝固.
- 在体内研究显示,与Celox Rapid相比,大鼠的出血时间减少.
结论:
- 开发的奇托桑-PC-800复合海绵是一种有前途的材料,可以快速有效地实现血静.
- 奇托桑和PC-800的协同作用有助于血液静止功效.
- 这种新型的静血带在紧急情况下为不受控制的出血提供了安全和快速的解决方案.
相关概念视频
01:05Introduction to Hemostasis
6.5K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
6.5K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
6.4K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
6.4K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
649
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
649