在基底类乳腺癌中非编码RNA生物标志物
Haider Ali1, Nawaid Hussain Khan2, Dalila Cano3
1Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.
概括
非编码RNAs (ncRNAs) 是基底类乳腺癌 (BLBC) 的关键调节者,为早期诊断和预后提供潜在的生物标志物. 基于ncRNA的疗法在改善治疗疗效和克服BLBC中耐药性方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 基底类乳腺癌 (BLBC) 是一种具有不良结果和有限治疗选择的侵袭性亚型.
- 准确的诊断和预后分层是BLBC管理中的关键挑战.
- 非编码RNAs (ncRNAs) 越来越多地被认为是癌症发展中的重要调节者.
研究的目的:
- 审查目前对ncRNA在BLBC瘤发生和进展中的作用的理解.
- 突出ncRNAs作为诊断和预后生物标记物的潜力.
- 讨论新兴的基于ncRNA的BLBC治疗策略.
主要方法:
- 关于BLBC中ncRNA功能的综合文献综述.
- 对ncRNA表达模式及其临床相关性的分析.
- 综合了基于ncRNA的诊断和治疗方法的数据.
主要成果:
- ncRNAs,包括miRNAs,lncRNAs,siRNAs和circRNAs,显著影响BLBC通路.
- 在体液中的稳定和亚型特定的ncRNA表达表明生物标记物的潜力.
- 基于ncRNA的疗法提供了针对BLBC和治疗耐药性的新策略.
结论:
- 在BLBC中,ncRNAs作为最小侵入性生物标志物具有显著的前景,用于早期检测,预后和治疗监测.
- 基于ncRNA的疗法代表了BLBC精准医学的一个有希望的途径.
- 需要进一步的研究来标准化测试和优化临床翻译的交付.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
02:55The Nucleolus
9.2K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
9.2K