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肠道和口腔微生物特征与口腔癌的关联

Junaid Nayyar¹, Cassandre Bedu-Ferrari², Dhrati Patangia²

¹Cork University Dental School & Hospital, Wilton, Co. Cork, T12 E8YV, Ireland.

Journal of dentistry

|June 2, 2025

概括

口腔和肠道微生物群可以作为早期口腔癌检测的生物标志物. 显而易见的微生物特征与恶性瘤有关,为风险评估提供了潜在的可能性.

科学领域:

微生物组研究的研究.
口腔瘤学在口腔瘤学.
转基因组学是指转基因组学.

背景情况:

人类微生物组影响健康和疾病.
口腔微生物组的改变与口腔疾病有关.
很少有研究基于组织学来探索口腔和肠道微生物组与口腔癌的联系.

研究的目的:

调查与口腔病变组织学相关的口腔和肠道微生物群概况.
为了确定口腔恶性瘤的潜在微生物生物标志物.

主要方法:

从30名参与者的口腔和肠道样本中进行了枪支元基因组测序.
参与者分为良性 (B),潜在恶性 (PM) 和恶性 (M) 口腔病变组.
微生物群概况的分析,以评估生物标志物潜力.

主要成果:

不同的肠道微生物特征区分为良性和恶性群体.
特定的口腔微生物 (例如, *Haemophilus parainfluenzae*, *Veillonella parvula*, *Fusobacterium nucleatum*, *Rothia mucilaginosa*) 与恶性瘤有很强的联系.
探索性数据表明,微生物组简介是潜在的口腔癌生物标志物.

结论:

口腔和肠道微生物组显示为早期口腔癌检测和风险评估的生物标志物具有前途.
由于异质性,需要对单个口腔潜在恶性疾病 (OPMD) 进行进一步的研究.
潜在恶性和恶性口腔病变的确定的生物标志物需要进一步调查.

关键词:

良性病变是一种良性病变.我们的肠道微生物组.恶性恶性恶性口腔癌是一种口腔癌.口腔微生物组是口腔的微生物组.口腔潜在的恶性病变 (OPMD)

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