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Updated: Mar 2, 2026

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins
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Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Published on: June 14, 2018

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通过Poxin转基因的DNA感应抑制增强NK细胞活性

Ling-Zu Kong1, Seok-Min Kim2, Soo Yun Lee2

  • 1Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.

Journal of advanced research
|June 2, 2025
PubMed
概括

毒素蛋白抑制了自然杀手 (NK) 细胞中的循环GMP-AMP合成酶 (cGAS) DNA感知,提高了它们对抗癌症的能力. 这增强了NK细胞介导的抗瘤活性和细胞毒性,改善了癌症治疗.

关键词:
细胞疗法是一种细胞疗法.检测DNA的感知器自然杀手细胞是自然杀手细胞.毒素毒素是一种毒素.

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