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苏辛酸通过分子开关促进FOXP3降解来驱动肠道炎症

Hai Wang1, Danqing Hu2, Yang Cheng1

  • 1Department of Pathology, Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Nature immunology
|June 2, 2025
PubMed
概括

增加的酸盐通过损害调节性T (Treg) 细胞促进炎症性肠病 (IBD). 苏酸减少FOXP3的表达,导致肠道炎症和IBD患者的免疫抑制降低.

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