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Updated: Jun 16, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Published on: November 5, 2019

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纵向和多位点采样揭示了转移性传播期间瘤的突变和复制数演变

Karena Zhao1,2,3, Joris Vos1,2, Stanley Lam1,2,3

  • 1Department of Surgery, Laboratory of Experimental Cancer Immunogenomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature genetics
|June 2, 2025
PubMed
概括

癌症转移主要涉及拷贝数变化 (CNA),而不是突变. 全基因组重复和9p的丧失是常见的事件,在免疫治疗患者中,增加的CNA与免疫逃避有关.

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