周年繁殖和甲基化受到Peromyscus中等午的影响
Kim-Tuyen Huynh-Dam1, Celia Jaeger2, Asieh Naderi1
1Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter Str., CLS 713, Columbia, SC, USA.
BMC biology
|June 2, 2025
概括
在受控环境中的动物表现出与出生月份相关的季节性繁殖,这表明超越光周期的环境线索会影响这些周年模式. 出生时的甲基化模式与这种季节性相关.
科学领域:
- 哺乳动物生殖生物学
- 表观遗传学和环境影响.
- 动物的行为和季节性.
背景情况:
- 光周期是哺乳动物周年模式的主要调节者.
- 在受控设施中的动物仍然可以显示繁殖季节性.
- 这项研究调查了Peromyscus殖民地几十年来的季节性.
研究的目的:
- 在长期控制条件下,确定Peromyscus小鼠是否存在季节性繁殖模式.
- 探索出生月份,甲基化和繁殖季节性之间的关系.
- 识别潜在的环境信号,调节光周期之外的环年节律.
主要方法:
- 分析了来自封闭的Peromyscus殖民地的97,000多个繁殖记录.
- 应用12节通用添加剂模型来确定季节性繁殖偏好.
- 评估与出生月份和季节相关的环年CpG甲基化模式.
主要成果:
- 后代产量显示季节性偏好受到母亲出生月份的影响,与春秋平衡相关的峰值.
- 出生的月份与周年CpG甲基化相关,而9月份的出生显示出最强烈的脱甲基化.
- 冬天出生的动物更喜欢夏天的,这与雌激期的周期长度和多妻性物种中的性腺激素释放激素分泌调节有关.
结论:
- 繁殖和甲基化周期性表明,非光周期信号调节鹿鼠的环年模式.
- 秋分,特别是秋天,似乎重新设置了这些季节节奏.
- 女性对这些调节信号的敏感性比男性更强.
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