适应糖尿病预防计划在西班牙初级保健环境中的影响:II型混合疗效实施集群随机试验 (ALADIM) 的协议
Miquel Bennasar-Veny1,2,3,4, Manuela Abbate5,6,7, Miquel Colom-Rosselló1,2,3
1Research Group On Global Health, University of Balearic Islands, 07122, Palma, Spain.
Implementation science : IS
|June 2, 2025
概括
阿拉迪姆研究适应了西班牙初级保健的糖尿病预防计划 (DPP),以应对不断上升的2型糖尿病 (T2D) 率. 这项试验评估了其在体重管理和预防糖尿病前期的实际实施中的有效性.
科学领域:
- 公共卫生 公共卫生
- 临床试验 临床试验
- 实施科学 实施科学
背景情况:
- 2型糖尿病 (T2D) 构成了重大的全球健康挑战,西班牙在欧洲患病率最高.
- 像糖尿病预防计划 (DPP) 这样的生活方式修改计划是有效的,但在临床环境中面临实施障碍.
- 阿拉迪姆研究解决了将基于证据的T2D预防策略纳入西班牙初级保健的必要性.
研究的目的:
- 评估西班牙初级保健中心 (PCC) 文化适应DPP的有效性和实施情况.
- 评估权重变化的主要结果和执行忠实性的副主要结果.
- 检查DPP实施对PCC内的整体糖尿病前期管理的溢出效应.
主要方法:
- 一个混合型II有效性实施集群随机对照试验,涉及10个PCC在西班牙马略卡.
- 将PCC随机分配给提供适应DPP的干预组或接受通常护理的对照组.
- 使用干预映射-ADAPT (IM-ADAPT) 方法和通过实施映射设计策略设计的DPP的文化适应.
主要成果:
- 有效性和溢出效应的结果将分别在参与者和PCC层面,在多个时间点进行评估.
- 实施结果将使用混合方法方法进行评估.
- 使用概括估计方程的治疗意图分析将确定有效性和溢出效应.
结论:
- 该研究旨在弥合T2D预防的研究和实践之间的差距.
- 调查结果将为开发T2D预防的可持续和可扩展的实施策略提供信息.
- 这项研究有可能影响糖尿病管理的区域和国家卫生政策和实践.
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