与代谢功能障碍相关的脂肪性肝病 (MASLD) 的管理 - - 从印度糖尿病专家的角度来看,一个专家的共识声明
Abdul Hamid Zargar1, Anil Bhansali2,3, Anirban Majumdar4,5
1Centre for Diabetes and Endocrine Care, Srinagar, India.
Diabetes, obesity & metabolism
|June 3, 2025
概括
由于糖尿病和肥胖,与代谢功能障碍相关的脂肪性肝病 (MASLD) 在印度正在上升. 糖尿病专家建议对高风险患者进行查,以便早期检测和管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 印度糖尿病和肥胖的患病率上升有助于增加与代谢功能障碍相关的脂肪性肝病 (MASLD),以前是非酒精性脂肪性肝病 (NAFLD).
- 无症状的性质和不断变化的MASLD诊断指南在高风险人群中准确估计患病率方面存在挑战.
- 需要提高糖尿病医生的意识,以便及时识别和管理MASLD.
研究的目的:
- 建立印度高风险人群中MASLD查,诊断和管理的共识指南.
- 为糖尿病医生提供一个实际的框架,以应对日益增长的MASLD负担.
- 引导未来的研究工作,以改善MASLD患者的治疗结果.
主要方法:
- 召集印度糖尿病专家小组,审查当前的证据和临床实践.
- 讨论和记录使用血清生物标志物,非侵入性工具和成像技术进行风险分层的方法.
- 评估治疗策略,包括改变生活方式和针对关键疾病途径的药理干预措施.
主要成果:
- 血清生物标志物,非侵入性工具和成像技术被确定为患者风险分层的关键要素.
- 早期的生活方式干预,如减肥和运动,已被证实对MASLD管理有益.
- 针对胰岛素耐药性,脂质代谢,炎症和纤维生成途径的不断扩大的药理选择提供了新的治疗途径.
结论:
- 开发的共识陈述为印度背景下MASLD查和管理提供了宝贵的指南.
- 这些指导方针旨在促进早期检测和干预,从而有可能减少MASLD的长期并发症.
- 预计这种共识将刺激精心设计的研究,以进一步提高MASLD的科学理解和临床管理.
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