相关实验视频

Updated: Sep 19, 2025

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

一个摄影驱动的免疫调节器与化学热疗法相结合,阻止了Helicobacter pylori感染的免疫检查点

Jie Li¹, Xianhui Song¹, Siyuan Huang¹

¹Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Advanced healthcare materials

|June 3, 2025

概括

这项研究介绍了BT@CPA,一种新的纳米抗剂,可以对抗Helicobacter pylori感染. 它结合了向药物输送,光热疗法和免疫调节,以克服抗生素耐药性和慢性感染.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

杆菌感染与胃部疾病有关,但抗生素耐药性和免疫逃避会给治疗带来挑战.
杆菌在胃细胞上调节PD-L1,促进T细胞亡和Treg分化,导致慢性感染.
目前的疗法由于效率下降和细菌免疫抑制而面临局限性.

研究的目的:

开发一种创新的纳米治疗策略来对抗H. pylori感染.
为了克服与H. pylori抗生素耐药性和免疫逃避相关的挑战.
为了创建一个全在一体的纳米抗剂,用于向治疗和免疫反应调节.

主要方法:

开发一种多功能纳米粒子 (BT@CPA),旨在捕获H. pylori.
使用NIR-II光辐射触发化疗和光热疗法.
加入抗PD-L1来阻止免疫检查点抑制.

主要成果:

BT@CPA有效捕获H. pylori,穿透胃粘膜,并通过轻度高温症增强抗生素敏感性.
纳米对手释放抗生素和抗PD-L1,对抗细菌并调节宿主免疫反应.
通过治疗组合,BT@CPA在预防H. pylori感染方面表现出有效性.

结论:

开发的BT@CPA纳米抗剂为H. pylori感染治疗提供了一个有前途的策略.
这种方法整合了化疗,光热疗法和免疫调节,以克服临床限制.
这些发现为通过解决免疫逃避机制来治疗传染病提供了新的方向.

关键词:

化疗敏感化化疗敏感化螺旋杆菌的感染螺旋杆菌的感染.免疫检查点是一个检查点.轻微的高温症或过热症

更多相关视频

One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode

One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode

Published on: June 18, 2016

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

相关概念视频

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...