甲状腺激素和大西洋三文鱼中中央皮质otropin释放因子系统之间的交叉声
Brett M Culbert1, Emily Jenkins1, Nicholas J Bernier1
1Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada.
Journal of neuroendocrinology
|June 3, 2025
概括
甲状腺激素 (THs) 影响大西洋鱼的皮质otropin释放因子 (CRF) 系统,通过CRF受体2 (CRFR2) 影响甲状腺刺激激素 (TSH) 的产生. 这揭示了远距离的鱼类中新的交叉通话机制.
科学领域:
- 内分泌学 在内分泌学.
- 神经内分泌学神经内分泌学
- 比较生理学比较生理学
背景情况:
- 皮质激素释放因子 (CRF) 系统调节垂体皮质激素活动,并影响非哺乳动物脊椎动物的甲状腺激素 (TH) 生产.
- 有限的研究存在于THs如何调节teleosts的CRF系统,而CRF刺激的TSH产生的特定途径仍然未知.
- 了解这些相互作用对于破译鱼类的神经内分泌调节至关重要.
研究的目的:
- 研究甲状腺激素 (THs) 与大西洋 (Salmo salar) 中央CRF系统之间的复杂相互作用.
- 为了阐明涉及到在teleosts中通过CRF介导的TSH生产的信号通路.
- 探索这些荷尔蒙系统相互作用的进化方面.
主要方法:
- 在体内,体外和内分析使用大西洋鱼进行.
- 在不同的TH条件下分析了CRF和受体的转录水平.
- 进行了对TH反应元素的CRF受体激活和促进体分析.
主要成果:
- 慢性升高的三甲氨酸 (T3) 特别影响了大脑中的CRF转录水平和 pituitary CRF受体2 (CRFR2b) 转录的增加,但不影响CRFR1.
- 在培养下垂体中,TSH (tshba) 转录仅在CRFR2激活时被上调,而CRFR1激活刺激了与皮质类基因相关的基因.
- 在大多数CRF系统组件的促进器中确定了假定TH响应元素,支持远程系统中的TH-CRF系统关系.
结论:
- 在远鱼中,THs与中央CRF系统之间交叉的新机制被揭示出来.
- CRFR2激活与TH介导的TSH产生有关,与调节皮质otropes的CRFR1通路不同.
- 这些发现为涉及THs和CRF系统的神经内分泌调节的演变提供了洞察力.
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