细胞外囊泡相关的tRFs作为乳腺癌中的新兴生物标志物
Md Sadique Hussain1, Liming Zhang2, Sumel Ashique3
1Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Dehradun, Uttarakhand, 248007, India.
细胞外囊泡衍生的tRNA片段 (EV-tRFs) 显示为乳腺癌 (BC) 检测和预后的非侵入性生物标志物具有前途. 它们的改变水平与BC亚型和患者的结果相关,提供了新的诊断和治疗途径.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 乳腺癌 (BC) 是癌症死亡的主要原因,需要改进非侵入性生物标志物.
- 目前的生物标志物具有局限性,特别是在三阴性乳腺癌 (TNBC) 等攻击性亚型中.
- 细胞外囊泡 (EVs) 是生物活性分子的新兴载体,包括tRNA衍生碎片 (tRFs),反映父母细胞状态.
研究的目的:
- 审查目前对乳腺癌中EV相关的tRFs的理解.
- 突出其作为诊断,预后和治疗监测的最小侵入性生物标志物的潜力.
- 讨论检测策略和临床应用的翻译潜力.
主要方法:
- 对乳腺癌中EV-tRF研究的系统文献综述.
- 分析tRFs在基因调节,细胞间通信和BC进展中的作用.
- 检查与BC特征相关的EV-tRF的差异表达模式.
主要成果:
- tRFs被选择性地丰富在EV中,并参与BC细胞间通信.
- 在EV中特定的5'-和3'-tRFs的差异表达与BC亚型,阶段和患者预后相关.
- 改变的EV-tRF水平与生存率差,转移和治疗耐药性有关.
结论:
- EV-tRFs代表了乳腺癌的有希望的,最少侵入性的生物标志物.
- 需要对tRF排序机制和功能影响进行进一步的研究.
- 在乳腺癌治疗中,EV-tRF具有作为新型治疗点的潜力.
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