使用更新的乙烯氧化物制造工人的死亡率研究,以告知癌症风险评估
Ciriaco Valdez-Flores1, Abby A Li2, Thomas J Bender3
1College of Engineering, Texas, USA.
概括
乙烯氧化物 (EtO) 的癌症风险评估因不同暴露模型而有很大差异. 这项对化学工人的研究没有发现证据支持在低EtO暴露下出现的癌症风险曲线,有利于标准模型.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 对乙烯氧化物 (EtO) 的癌症风险评估显示出显著的差异.
- 这些差异源于在风险估计中使用的不同暴露-反应模型.
- 国家职业安全与健康研究所 (NIOSH) 的研究是EtO风险的关键参考.
研究的目的:
- 为了研究EtO暴露-反应曲线的形状.
- 分析一个更新的联合碳化工公司 (UCC) 化学工人队列.
- 将发现与现有的NIOSH队列数据进行比较.
主要方法:
- 对10年更新的UCC EtO工人队伍的分析.
- 使用累积暴露指标的连续剂量反应建模.
- 结果与UCC和NIOSH队列的分类概率比率估计进行了比较.
主要成果:
- 更新的UCC队列分析没有提供经验证据支持在低暴露水平下出现的EtO暴露-反应曲线.
- 连续剂量反应建模没有表明非线性关系.
- 跨队列更新和性别的分类分析倾向于标准的考克斯比例危险 (CPH) 模型.
结论:
- 标准CPH模型似乎更合理地描述了EtO暴露与淋巴癌死亡率之间的关系.
- 来自独立队列的流行病学证据表明,线性推断可能是适当的.
- 进一步的研究应该考虑EtO风险评估中的暴露-反应关系的形状.
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