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单剂量psilocybin改变了身体形障碍症患者的休息状态功能网络

Xi Zhu^1,2, Chen Zhang², David Hellerstein¹

¹Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Psychedelics

|June 3, 2025

概括

西治疗对身体形障碍 (BDD) 的治疗有希望. 在执行控制网络内休息状态功能连接的亚急性增加预测了BDD患者的症状改善. 需要进一步的研究.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

身体形障碍 (BDD) 是一种严重的精神疾病,涉及对外观缺陷的关注.
一种迷幻化合物psilocybin正在研究其在精神疾病中的治疗潜力.

研究的目的:

为了识别BDD的成年人中预测对psilocybin的症状反应的亚急性神经改变.
探索psilocybin对BDD患者静止状态功能连接 (rsFC) 的影响.

主要方法:

八名患有BDD的成年人接受了单次25毫克的 псилоцибин剂量,并得到了心理支持.
休息状态功能性磁共振成像 (rs-fMRI) 测试在西宾服药前和1天后进行.
兴趣区域 (ROI) 到ROI和多变量模式分析 (MVPA) 用于分析预测症状改善的rsFC变化.

主要成果:

在第1周和第12周,psilocybin治疗导致BDD症状显著减少.
在执行控制网络 (ECN) 中观察到 rsFC 显著增加,剂后 1 天.
增加ECN内部和ECN与其他网络之间的rsFC预测症状改善.

结论:

这项研究提供了第一个证据,证明了psilocybin在BDD患者中对大脑的亚急性影响.
在rsFC的变化,特别是在ECN内,可以作为在BDD中治疗psilocybin反应的生物标志物.
需要进行更大规模的受控研究来验证这些初步发现.

关键词:

身体形障碍身体形障碍功能连接性的功能连接性这种药物是psilocybin.休息状态 fMRI 的状态.治疗对治疗的反应反应.

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