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在HCC与非HCC肝移植接受者的长期生存和复发:二十年的纵向分析

Mahmoudreza Moein¹, Bridgette Nixon¹, Michael Leyderman¹

¹SUNY Upstate Medical University, Division of Transplant Services, Department of Surgery, Syracuse, NY, USA.

Journal of clinical and experimental hepatology

|June 3, 2025

概括

近年来,肝细胞癌 (HCC) 的肝移植 (LTs) 显示出更好的生存结果. 遵守米兰标准显著提高了LT接受者的患者和全移植生存率.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 是肝移植 (LT) 的主要指示.
将HCC患者的LT长期生存结果与其他肝脏疾病进行比较对于治疗困境至关重要.
在过去二十年中,LT协议和患者选择的进步一直在不断发展.

研究的目的:

为了比较肝移植 (LT) 接受者与肝细胞癌 (HCC) 与其他肝病患者的长期生存结果.
评估米兰标准对LT接受者的生存的影响.
评估HCC和非HCC患者LT结局的时间趋势.

主要方法:

对移植受体科学注册 (SRTR) 数据库的回顾性分析.
包括2000年1月至2023年6月在美国进行的143717起LT病例.
两个队列之间的结果比较:2001-2010年和2011-2023年,按HCC和非HCC诊断分层.

主要成果:

与2001-2010年相比,在HCC和非HCC患者中,在2011-2023年队列中观察到1年和5年全移植生存率的显著改善.
符合米兰标准的患者表现明显更好,在此期间后,观察到5年生存率有10%的差异.
在非HCC组中,在两个时间框架内都发现了急性和慢性排斥的更高率.

结论:

肝移植 (LT) 对肝细胞癌 (HCC) 患者的结果与过去十年中其他迹象相比较.
遵守米兰标准对于优化全移植和LT接受者的患者存活率至关重要.
这项研究强调了当符合适当的选择标准时,LT对HCC的有效性.

关键词:

在MELD中,得分是MELD.肝细胞癌 (HCC) 是一种肝细胞癌.肝移植肝移植肝移植长期的结果是长期的结果."米兰标准"是指米兰的标准.

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