子的健康状况感染了不同病变得分的sarcoptic mange 和不同的病变得分
Marwa M Attia1, Amira M Ibrahim2, Osama G Sakr3
1Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211 Egypt.
概括
在子中感染Sarcoptes scabiei会导致营养不良和皮肤病变. 较高的损伤得分与血清中氧化物增加以及脏和皮肤中主要基因相容性I类 (MHC-I) 基因表达的增加相关.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
背景情况:
- Sarcoptes scabiei会在子中引起,导致严重的健康问题.
- 临床症状包括皮肤病变,,毛皮脱落和瘦身.
- 了解免疫反应对于管理肉眼的管理至关重要.
研究的目的:
- 评估感染Sarcoptes scabiei. 的子的健康状况.
- 为了将病变的严重程度与特定的免疫标志物相关联:血清氧化 (NOx) 和主要基因相容性I类 (MHC-I) 表达.
- 通过分子方法识别Sarcoptes scabiei.
主要方法:
- 检查了200只家是否感染了Sarcoptes scabiei.
- 根据皮肤异常的位置和严重程度进行了损伤评分.
- 在皮肤和脏中量化了血清NOx水平和MHC-I mRNA表达.
- ITS2基因测序用于虫识别和植物遗传学分析.
主要成果:
- Sarcoptes scabiei虫通过ITS2基因测序 (加入号) 进行鉴定. (PQ130162) 在这里.
- 血清中氧化物 (NOx) 含量随着病变得分的提高而显著增加.
- 在皮肤和脏中检测到主要基因相容性I类 (MHC-I) mRNA表达,脏中的水平更高.
- MHC-I转录水平也与病变严重程度成比例增加.
结论:
- 萨科普特虫 (Sarcoptes scabiei) 感染会对子的健康产生负面影响,导致营养不良和皮肤损伤.
- 血清NOx升高和MHC-I表达增加表明对虫感染的炎症和免疫反应.
- 脏似乎是MHC-I在子中Sarcoptes scabiei感染期间表达的重要部位.
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