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相关概念视频

Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

685
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
685
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

1.1K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
1.1K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.2K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.2K

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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奎瑞-尤德拉吉特®聚合物复合物具有增强的负载,可溶性,稳定性和特定地点的准.

Siddharth S Kesharwani1, Casey L Sayre1,2, Sharyu Kesharwani3

  • 1College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT, USA.

Therapeutic delivery
|June 3, 2025
PubMed
概括

这项研究开发了一种基于聚合物的平台,以改善向结肠输送氨酸. 新的奎尔塞丁-尤德拉吉特®复合物显示出增强的溶解性,稳定性和对结肠癌细胞的有效性,克服了生物可用性挑战.

关键词:
欧德拉吉特® S100 的使用方法欧德拉吉特®聚合物的聚合物奎尔丁 (Quercetin) 是一种青素.和配方开发和配方开发.结肠的准是针对结肠的需要依赖pH的输送.聚合物复合物的聚合物复合物.特定地点的交付服务.

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 材料科学 材料科学 材料科学
  • 药物运输 药物运输 药物运输

背景情况:

  • Quercetin 是一种天然化合物,在预防慢性疾病方面表现有前途.
  • 由于可溶性和透性较低,思的口服生物可用性较差,限制了其治疗应用.
  • 需要有针对性的输送系统来提高奎尔塞丁的有效性.

研究的目的:

  • 开发一种基于聚合物的平台,用于针对性地向结肠输送奎尔丁.
  • 为了改善奎尔丁的溶解性,稳定性和口服吸收.
  • 评估在结肠癌细胞中开发的瑞聚合物复合物的疗效.

主要方法:

  • 使用与Eudragit® S100/L100/L100-55聚合物的共同沉来制备奎尔塞丁复合物.
  • 乙醇和聚乙烯醇分别被用作溶剂和表面活性剂.
  • 描述包括负载能力,溶解性,稳定性和体外细胞毒性测试.

主要成果:

  • 聚合物复合物表现出高素负载能力 (~315μg/mL).
  • 复合物表现为无形性质,在pH值>5.5的溶解度,以及显著增加的水溶性 (>1 mg/mL).
  • 观察到增强的稳定性 (>30小时) 和改善的结肠癌细胞活力的降低 (HCT116,HT29).

结论:

  • 成功开发了一种聚合物 - 瑞复合物,用于向结肠输送.
  • 开发的复合体显示了更好的负载,溶解度,稳定性和增强的抗癌活性.
  • 这个平台提供了一种有希望的方法来克服奎尔素的生物可用性限制.