由于被污染的补充剂导致的不良分析结果后,没有过错或疏忽:任务不可能. 两个例子涉及三甲丁
Pascal Kintz1,2
1X-Pertise Consulting, Mittelhausbergen, France.
Clinical chemistry and laboratory medicine
|June 3, 2025
概括
食品补充剂对运动员构成污染风险,导致违反反兴奋剂规则,即使含有微量禁止物质,如三甲. 法医分析表明污染不是兴奋剂,主张进行头发检测和尿液度值.
科学领域:
- 运动科学 运动科学 运动科学
- 分析化学 分析化学
- 法医毒理学 法医毒理学
背景情况:
- 运动员经常使用食补充剂,尽管世界反兴奋剂机构 (WADA) 等体育当局对可能受到禁止物质污染的警告.
- 与补充剂相关的兴奋剂违规行为很常见,经常检测到类固醇,SARM,代谢调节剂,兴奋剂和利尿剂.
研究的目的:
- 为了调查由于补充剂污染而在运动员的尿液中检测到禁用物质三甲的情况.
- 在反兴奋剂规则违规的背景下,分析尿液和头发样本中低水平的trimetazidine检测的法医影响.
主要方法:
- 对两名运动员的案例研究分析,他们因尿液中含有三甲而受到制裁.
- 分析尿液和头发样本的trimetazidine.
- 在涉及的食品补充剂中对三甲素的量化.
主要成果:
- 在运动员的尿液中检测到低度的trimetazidine (0.1-1.6 ng/mL) 和补充剂 (4 ng/片和7.2 μg/片).
- 两名运动员的头发样本检测出trimetazidine的阴性,尽管检测极限很低.
- 运动员被禁赛6个月,尽管有证据表明污染而不是故意使用兴奋剂.
结论:
- 在尿液中检测到低水平的三甲,即使是阴性头发检测,也导致违反反兴奋剂规则和制裁.
- 从法医的角度来看,污染应该与故意的兴奋剂区分开来.
- 实施毛发检测和尿液度值可以解决因补充剂污染病例而产生的冲突.
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