过渡到延长释放布普伦诺芬注射在七天内用于阿片类药物使用障碍治疗:一个大范围的叙述
Journal of addiction medicine
|June 3, 2025
概括
在7天内将患有阿片类药物使用障碍的患者转换为长效注射布普伦诺芬 (Bup-XR-S或Bup-LA-B) 是可行的,并且耐受良好. 这种快速启动支持治疗的坚持,并减轻高风险人群中过量服用的风险.
科学领域:
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 阿片类药物使用障碍 (OUD) 治疗通常涉及每天的透管布伦诺芬,这对坚持和过量预防构成了挑战.
- 延长释放注射布诺芬配方 (Bup-XR-S和Bup-LA-B) 提供较少的剂量,可能改善患者的治疗结果.
- 快速过渡到注射性布普伦诺芬是一种有前途的策略,可以迅速稳定患者,特别是在普遍存在的强效非法阿片类药物中.
研究的目的:
- 评估OUD患者在最后一次舌下剂量后7天内转换为长效注射布普伦诺芬配方 (Bup-XR-S和Bup-LA-B) 的结果.
- 评估可行性,耐受性和与快速启动注射性布普伦诺芬治疗相关的坚持.
- 在管理OUD时识别加速诱导协议的潜在风险和好处.
主要方法:
- 在MEDLINE和EMBASE进行了系统的文献搜索,截至2025年2月14日.
- 包括的研究重点是OUD患者过渡到Bup-XR-S或Bup-LA-B.
- 提取的数据包括患者特征,剂量,保留率和合成不良事件.
主要成果:
- 包括534名患者在内的21项研究符合纳入标准.
- 评估了快速过渡 (24小时内) 到Bup-XR-S和Bup-LA-B的情况.
- 短期保留 (4周) 超过60%,罕见和轻度不良事件;4%的Bup-XR-S患者需要额外的阿片类药物支持.
结论:
- 在7天内过渡到Bup-XR-S似乎是可行的,耐受良好,并支持OUD患者的坚持.
- 在标记剂量后的24小时内,Bup-LA-B过渡是有效的,并且耐受良好.
- 加快注射布诺芬的启动可能有助于启动OUD治疗并减轻过量服用的风险,这需要进一步研究长期有效性和保留.
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