女性特异性癌症幸存者的激素替代疗法:癌症治疗之外的考虑
Tomoko Yoshihama1, Megumi Yokota1, Daisuke Aoki1,2,3
1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Japanese journal of clinical oncology
|June 3, 2025
概括
激素替代疗法 (HRT) 通常对宫,子宫内膜和卵巢癌幸存者来说是安全的,但对乳腺癌幸存者来说是禁忌的. 本综述更新了证据,以指导HRT决策,以改善癌症患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 妇科 妇科医生 妇科
- 内分泌学 在内分泌学.
背景情况:
- 癌症治疗可以导致过早的卵巢衰竭,影响女性幸存者的生活质量.
- 激素替代疗法 (HRT) 是一种潜在的干预措施,但其瘤安全性令人担忧.
- 关于癌症幸存者的HRT安全性的证据需要定期更新.
研究的目的:
- 为在有宫癌,子宫内膜癌,卵巢癌和乳腺癌史的妇女中提供HRT使用的最新概述.
- 根据癌症类型和阶段来评估HRT的安全性和禁忌.
- 为医疗保健提供者提供有关癌症幸存者的HRT益处和风险的信息.
主要方法:
- 对女性癌症幸存者的HRT当前文献的系统综述.
- 对不同癌症类型的HRT进行禁忌和安全数据的分析.
- 对宫,子宫内膜,卵巢和乳腺癌的证据综合.
主要成果:
- 对于宫癌 (状细胞癌,腺癌),无论何种阶段,HRT均不禁用.
- 对于没有残留瘤的早期子宫内膜癌,HRT没有禁忌,但在低度子宫内膜层肉瘤中应避免.
- 对于上皮卵巢癌,HRT没有禁忌,除了低度血清性癌症.
- 对于乳腺癌,HRT仍然是禁忌.
结论:
- 对于某些妇科癌症的幸存者来说,可以考虑HRT,改善生活质量.
- 仔细的患者选择和监测对于癌症幸存者使用HRT至关重要.
- 对于癌症幸存者来说,向终身健康管理的转变是必不可少的,无法治愈.
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