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持续使用抗痴呆药物:系统性审查和元分析
Mohammad Sistanizad1,2, Gregory M Peterson1, Tristan Ling1
1University of Tasmania, School of Pharmacy and Pharmacology, Hobart, Australia.
Age and ageing
|June 3, 2025
概括
抗痴呆药物 (ADD) 的持续性很低,只有49%的患者在12个月后继续治疗. 改善对ADDs的坚持对于更好的痴呆症患者结果至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 抗痴呆药物 (ADD) 的低最佳持续性与痴呆患者的不良结果有关,包括疾病进展的加快和医疗保健使用的增加.
- 了解现实世界持续率和影响因素对于改善痴呆症护理至关重要.
研究的目的:
- 系统地审查与抗痴呆药物 (ADDs) 的真实世界持久率.
- 确定影响患者抗痴呆药物治疗持续性的因素.
主要方法:
- 根据柯克兰和PRISMA指南进行系统审查和元分析.
- 在多个数据库 (Medline,Embase,PsycINFO,CINAHL) 搜索了1995年1月至2024年2月期间发表的研究.
- 使用随机效应模型计算聚合持久率,并通过元回归探索异质性.
主要成果:
- 包括68项研究,684,493名50岁以上的参与者接受了ADDs.
- 平均12个月持久率为49% (95% CI:42%-56%).
- 观察到更高的持久性,当一个允许的空白的补充是不需要 (67%),为美曼丁 (61%),在2011-2015年的研究 (54%),在欧洲研究 (57%).
结论:
- 分析表明,ADD的持续性通常很低,受评估方法的影响.
- 需要有针对性的干预措施来增强ADD的持续性和改善痴呆患者的治疗结果.
- 建议采用标准化框架来测量持续性,以提高研究的一致性.
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