人类牛奶寡糖调解了模型阴道社区的宿主-微生物接口.
Julie A Talbert1, Sabrina K Spicer1, Shannon D Manning2
1Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, United States.
ACS infectious diseases
|June 3, 2025
概括
人类牛奶寡糖 (HMO) 和乳酸菌促进健康的阴道微生物群,降低怀孕期间B组链球菌 (GBS) 感染的风险. 这种预益生菌和益生菌方法提供了一种新的治疗策略,可以预防不良怀孕和新生儿后果.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 免疫学 免疫学 免疫学
背景情况:
- 乙组链球菌 (GBS) 导致严重的妊娠期感染,治疗选择有限.
- 目前的GBS治疗不能预防胆膜炎,早产或晚发性疾病.
研究的目的:
- 调查人类牛奶寡糖 (HMO) 和乳酸菌对治疗GBS感染的治疗潜力.
- 评估HMO对阴道微生物组合和GBS-Lactobacillus相互作用的影响.
主要方法:
- 在体外共同培养的GBS和Lactobacillus spp.的模型. 与HMO合作.与HMO合作.与HMO合作.与HMO合作.
- 对乳酸菌粘附于阴道组织的ex vivo分析.
- 在GBS生殖道感染的体内小鼠模型.
主要成果:
- 在体外培养中,HMO转移到有利于Lactobacillus spp.,通过扫描电子显微镜可视化.
- 在GBS共过程中,HMO增强了乳酸菌对阴道组织的粘附.
- 结合的Lactobacillus crispatus和HMOs在小鼠模型中阻止了GBS感染的上升,减少了胎盘和胎儿的细菌负担.
结论:
- HMO和乳酸菌积极调节阴道微生物群,抑制GBS.
- 益生菌 (HMO) 和益生菌 (Lactobacillus) 的干预措施显示出减少妊娠期间GBS殖民的希望.
- 这种方法可能提供一种新的策略,以防止与GBS相关的不良怀孕和新生儿后果.
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