在受伤后弱的干扰素-γ与慢性严重疾病有关
Joseph Cuschieri1, Lucy Z Kornblith, Hashem Kalthoum
1From the Department of Surgery (J.C., L.Z.K., H.K., S.C.), University of California San Francisco, San Francisco California (S.P.), University of California San Francisco; and Department of Pediatrics (A.P.), University of Washington, Seattle, Washington.
严重受伤后干扰素马 (IFN-γ) 水平较低,预测慢性严重疾病 (CCI). 这种免疫标志物与单细胞功能减少和较差的长期结果有关,包括死亡率增加.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 基因组学就是基因组学.
背景情况:
- 干扰素 (IFN) -γ的基因组表达变化与严重损伤后的器官衰竭有关.
- IFN-γ对先天免疫力和长期结果的影响仍未得到充分研究.
研究的目的:
- 研究IFN-γ在单细胞功能中的作用.
- 确定IFN-γ水平与慢性严重疾病 (CCI) 的发展之间的关联.
主要方法:
- 重度受伤患者的前性评估 (发展队列n=124,验证队列n=78).
- 在受伤后12小时内通过免疫测试测量血IFN-γ水平.
- 在验证队列中分析了单细胞激活和人类白细胞抗原-DR表达.
主要成果:
- IFN-γ水平≤50 pg/mL与CCI发展独立相关.
- 较低的IFN-γ与减少的单细胞激活和HLA-DR表达相关.
- 在验证队列中,低IFN-γ预测了增加的CCI,医院感染,不良排放和1年死亡率 (25%vs4%).
结论:
- 在严重受伤后早期降低IFN-γ水平可预测CCI.
- 这种减少与单细胞功能受损和较差的长期结果有关.
- IFN-γ可以作为预后生物标志物,用于识别可能受益于向治疗的患者.
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