连续调解:乐观如何减少,悲观如何加剧慢性腰痛通过抑郁症和生物衰老
Khalid W Freij1, Fiona B A T Agbor1, Vinodh Srinivasasainagendra2
1Department of Acute, Chronic, & Continuing Care, Nurse Anesthesia Program, School of Nursing, The University of Alabama at Birmingham, Birmingham, AL, USA.
Biological research for nursing
|June 3, 2025
概括
乐观和悲观通过影响抑郁症状和生物衰老来影响慢性腰痛 (CLBP). 改善心理健康可能会减缓衰老并减少CLBP的严重程度.
科学领域:
- 心理学 心理学 心理学
- 老年学是指老年学的学科.
- 疼痛医学 医学 疼痛医学
背景情况:
- 乐观,悲观和抑郁症状等心理因素与慢性腰痛 (CLBP) 有关.
- 生物衰老,特别是衰老的速度,越来越被认为是健康结果的因素.
- 心理状态,生物衰老和CLBP之间的相互作用需要进一步研究.
研究的目的:
- 调查乐观主义/悲观主义,抑郁症状,生物衰老速度和CLBP严重程度/干扰之间的关系.
- 为了测试抑郁症状和从表观基因组 (DunedinPACE) 的衰老速度是否连续介导乐观/悲观和CLBP结果之间的联系.
主要方法:
- 调解分析被用来检查串行路径.
- 参与者包括非西班牙裔黑人和白人成年人在无疼痛,低影响疼痛和高影响疼痛组.
- DunedinPACE被用来测量生物衰老的速度.
主要成果:
- 与其他组相比,具有高影响力CLBP的个体报告的乐观程度较低,悲观程度更高,和更快的DunedinPACE.
- 抑郁症状和DunedinPACE连续调解了乐观/悲观和CLBP严重程度/干扰之间的关联.
- 这些间接影响在对年龄,性别,种族和BMI进行控制后并不显著.
结论:
- 针对乐观和悲观的心理干预可能会影响生物衰老的速度.
- 通过心理手段减缓生物衰老可能会改善CLBP的结果.
- 这些发现突出了心理健康,生物衰老和慢性疼痛之间的复杂相互作用.
相关概念视频
Depressive Disorders: Etiology
173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Stress and Mental Health
221
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
221
Depression: Overview
371
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
371
Long-term Depression
31.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.5K
Depressive Disorders: MDD and Dysthymia
225
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
225
Self-Discrepancy and Its Effects
8
Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...
8


