一个患有肝硬化相关免疫功能障碍的患者的非HIV肺囊炎肺炎病例
Kai Miyamoto1, Yoshihito Uchida2, Shohei Tsuji2
1Clinical Training Center, Saitama Medical University Hospital, Saitama, Japan.
Clinical journal of gastroenterology
|June 3, 2025
概括
肝硬化相关的免疫功能障碍 (CAID) 可能会增加晚期肝病患者肺囊性肺炎 (PCP) 的风险. 监测这些患者的淋巴细胞计数对于早期发现和治疗机会性感染至关重要.
科学领域:
- 医学 医学 医学 医学 医学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 与酒精有关的肝硬化会导致免疫功能障碍,增加对感染的易感性.
- 机会性感染,如肺囊性肺炎 (PCP),可危及免疫功能低下个体的生命.
研究的目的:
- 在患有晚期肝硬化病的患者中报告非艾滋病毒肺囊炎肺炎 (PCP) 的病例.
- 突出肝硬化相关免疫功能障碍 (CAID) 在PCP易感性方面的潜在作用.
- 强调监测肝硬化患者的淋巴细胞计数的重要性.
主要方法:
- 一个55岁的男性患有与酒精有关的肝硬化病例报告.
- 临床表现包括呼吸障碍和肺部成像特征发现 (地面玻璃不透明).
- 诊断工作涉及升高的β-D-葡萄糖,KL-6,和阳性液PCR肺囊 jirovecii.
主要成果:
- 患者被诊断为非艾滋病毒PCP,尽管人类免疫缺陷病毒 (HIV) 测试呈阴性.
- 在入院前,周围淋巴细胞计数低于500/μL,这表明CAID.
- 尽管接受了治疗,但患者因感染而死亡.
结论:
- 晚期肝硬化可能与免疫功能障碍 (CAID) 相关,使患者易患PCP等机会性感染.
- 在肝硬化患者中监测周围淋巴细胞计数对于识别有风险的个体至关重要.
- 在患有CAID的患者中,早期识别和管理非艾滋病毒PCP至关重要.
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