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费诺纤维酸减轻乳腺癌患者多克索鲁比诱导的心脏毒性:一项随机对照试验
Hagar K Dewidar1, Amr A Ghannam2, Tarek M Mostafa3
1Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt. hagar.dewidar@pharm.tanta.edu.eg.
Naunyn-Schmiedeberg's archives of pharmacology
|June 3, 2025
概括
费诺纤维酸在预防乳腺癌患者的多克索鲁比诱导心脏毒性 (DIC) 中表现有前途. 这项研究发现,与对照人群相比,纤维酸保持了左心室喷射分数 (LVEF) 和降低了心脏毒性标志物.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- doxorubicin 诱导的心脏毒性 (DIC) 是化疗的一个显著限制.
- 接受多克索鲁比的乳腺癌患者有心脏损伤的风险.
- 需要有效的心脏保护策略来改善治疗结果.
研究的目的:
- 评估芬诺纤维酸在预防乳腺癌患者的DIC中的疗效和安全性.
- 评估纤维酸对左心室喷射率 (LVEF) 和心脏生物标志物的影响.
- 为了确定化学疗法期间的费诺纤维酸的耐受性.
主要方法:
- 一项随机对照并行研究,涉及44名II/III期乳腺癌患者.
- 患者接受了单独的多克索鲁比/cyclophosphamide (AC) 化疗 (对照) 或AC加 fenofibrate.
- 心声和血清生物标志物分析 (NT-proBNP,MPO,ALT,AST) 在基线和化疗后进行.
主要成果:
- 与对照组相比,费诺纤维酸盐组的LVEF显著更高,心脏毒性发病率较低.
- 纤维酸显著降低了NT-proBNP和MPO的血清水平,这是心脏压力和炎症的关键指标.
- 费诺纤维酸盐耐受性良好,并且不会导致肝酶 (ALT,AST) 显著升高.
结论:
- 费诺纤维酸证明了作为预防性治疗对多克索鲁比诱导的心脏毒性的潜力.
- 这些发现表明,纤维酸可以保持心脏功能,并减少乳腺癌患者接受化疗的心脏毒性标志物.
- 费诺纤维酸为缓解化疗相关心脏不良事件提供了一种安全和有前途的选择.
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