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从临床 (UPEC) 和环境样本中分离出的多药耐药性大肠杆菌的表征

Eman M Farahat¹, Noha A Hassuna², Adel M M Hammad³

¹Minia Higher Technology Institute for Applied Health Sciences, Minia, Egypt. EmanMahmoud@science.bsu.edu.eg.

Molecular biology reports

|June 3, 2025

概括

在埃及的废水和尼罗河水中,存在多种耐药性大肠杆菌 (E. coli),对尿路感染 (UTI) 构成重大威胁. 更好的监测对于控制这些耐药细菌的传播至关重要.

科学领域:

环境微生物学环境微生物学
临床微生物学临床微生物学
抗微生物耐药性抗微生物耐药性

背景情况:

大肠杆菌 (E. coli) 是导致尿路感染的主要病原体.
了解大肠杆菌在环境来源中的流行和耐药性模式对于公共卫生至关重要.

研究的目的:

调查E. coli在经过处理的废水和尼罗河水中的流行率和抗菌素耐药性概况.
为了比较来自环境来源的大肠杆菌分离物与埃及人类尿路感染患者的分离物.

主要方法:

收集了1040个样本:57个是经过处理的废水,400个是尼罗河水,以及583个来自尿路感染患者的尿样 (2019年9月至2020年3月).
评估了大肠杆菌的流行,扩展谱β-乳糖酶的产生 (ESBLEC) 和多药性耐药性 (MDR).
对尿病原性大肠杆菌菌株 (UPEC) 进行了遗传学分析.

主要成果:

大肠杆菌在废水 (84.2%) 和河水 (63.3%) 中高度流行,在33.5%的尿样中检测到.
所有ESBLEC分离物体都对青素和塞菲姆药物表现出耐药性. 在废水 (70.7%) 和河流 (87%) 中观察到高MDR率.
临床大肠杆菌分离物表现出62.5%的MDR,但仍然主要对西普罗夫洛克萨和美罗胺敏感.

结论:

污水处理厂充当了具有多药性耐药性大肠杆菌的重要储库.
环境中的大肠杆菌菌株表现出耐受性,这表明有可能广泛传播.
埃及迫切需要加强监测和控制措施,以打击MDR大肠杆菌的传播.

关键词:

在 CTX-M 组中.埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.人类遗传学学.废水是废水,废水就是废水.

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