患有不同类型结石的患者的尿液微生物组概况
Muhammed Manzoor1, Mangesh Vasant Suryavanshi1,2,3, Musliyarakath Mujeeburahiman4
1Division of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya Deemed to be University, Mangalore, Karnataka, 575018, India.
FEMS microbiology letters
|June 3, 2025
概括
尿路微生物组 (UMB) 的组成在患有结石疾病 (KSD) 的患者中不同. 像Corynebacterium和Staphylococcus这样的特定细菌在KSD患者中更为丰富,提供了新的治疗点.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 结石疾病 (KSD) 是多因素的,受饮食,遗传和代谢因素的影响.
- 尿路微生物组 (UMB) 在KSD中的作用是建议的,但在不同类型的石头中不清楚.
- 了解各种KSD亚型的UMB对于开发有针对性的疗法至关重要.
研究的目的:
- 分析和比较患有四种不同的结石类型的患者的UMB组成:氧沙酸,斯特鲁维特,尿酸和混合.
- 为了识别与不同KSD亚型相关的特定微生物特征.
- 探索KSD患者UMB和代谢参数之间的相关性.
主要方法:
- 16S rRNA基因测序用于分析KSD患者和对照组的尿样.
- 对不同类型的石头和健康对照的微生物组成进行了比较.
- 进行了微生物组成和血液/尿液参数之间的相关性分析.
主要成果:
- 与对照组相比,KSD患者的UMB组成不同,Corynebacterium,Prevotella和Staphylococcus的增加.
- 在纯石和混合石的形成者之间,Dongia和Stenotrophomonas的丰度有所不同.
- 与对照人群相比,形成石头的氧化酸盐有 Pseudomonas 和 Dongia 的增加,而 Peptoniphilus 的减少.
- 两组之间没有观察到微生物多样性的显著差异.
- UMB组成与血液和尿液参数相关.
结论:
- UMB在结石疾病的发展中发挥着重要作用.
- 特定的微生物形状与不同类型的结石有关.
- 研究结果表明,对于KSD,基于微生物组的治疗策略具有潜力.
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