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Updated: Sep 19, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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通过受损的DNA预复制复合体功能阻碍对PARP的抗性而独立于BRCA2逆转基因突变

Kyrie Pappas1, Matteo Ferrari2, Perianne Smith3

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Proceedings of the National Academy of Sciences of the United States of America
|June 3, 2025
PubMed
概括

在前列腺癌中,PARPi耐药性与DNA预复制复合物有关. 针对这个复合体可能会恢复BRCA突变瘤中的PARPi敏感性.

关键词:
CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1在PARP中,PARP是PARP.双子座的双胞胎是什么意思同类的重组组合.前列腺前列腺前列腺

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