超直流刺激神经调节人体内内认知唤起的活动
Mireille Tabikh1, Tom Quetu1, Louis Maillard1,2
1Ingenierie Moleculaire, Cellulaire et Physiopathologie, UMR7365, CNRS and University of Lorraine, Nancy F-54000, France.
概括
使用高清电极的低强度跨直流刺激 (tDCS),通过患者的内EEG (iEEG) 记录的显著调节的面部选择性大脑活动,证明了可靠的神经生理效应.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 生物医学工程 生物医学工程
背景情况:
- 超直流刺激 (tDCS) 是一种非侵入性脑刺激技术,具有潜在的认知康复.
- 头皮脑电图 (EEG) 对tDCS影响的研究通常显示可靠性较低.
- 内EEG (iEEG) 为量化大脑活动提供了更高的分辨率.
研究的目的:
- 通过iEEG研究tDCS对认知唤起反应的神经调节效应.
- 评估tDCS诱导的大脑活动变化的可靠性和特异性.
- 探索高清tDCS电极用于有针对性的脑刺激的潜力.
主要方法:
- 虚拟控制的tDCS实验,在右角-角皮层上进行阳极刺激 (+2 mA).
- 在11名耐药患者的947名接触者同时进行iEEG记录,这些患者在快速周期性视觉刺激过程中进行了快速周期性视觉刺激.
- 在 (P2) 和 (P3) tDCS期间与tDCS前基线 (P1) 相比,对iEEG信号的分析.
主要成果:
- 在叶和叶观察到面部选择性EEG活动的显著神经调节.
- 在tDCS期间和之后,面部选择性反应的幅度增加范围从3%到36%.
- 在tDCS (P3与P1,P=0.015) 后,右角时间皮层的面部选择性神经调节仍然存在.
结论:
- 使用小环电极的低强度tDCS可以诱导对选择性认知功能的显著,可靠的电生理学影响.
- iEEG提供了一种敏感的方法来量化tDCS诱导的神经调节.
- 这项研究支持使用tDCS用于有针对性的认知增强和康复.
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