在儿科发病多发性硬化症中的表观遗传衰老.
Christopher Goyne1, Ashley E Fair1, Defne Yilmaz2
1Department of Neurosciences, University of California San Diego, CA.
Neurology
|June 3, 2025
概括
儿科发病多发性硬化症 (MS) 与加速的生物衰老有关,根据表观遗传钟的测量. 这表明,即使在年轻人中,MS也可能导致过早衰老.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 儿科神经学 儿科神经学
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 的年龄较大与复发率降低和疾病进展增加有关.
- 通过表观遗传标记来评估生物年龄,可能比时间年龄更准确地衡量衰老效应.
- 与MS相关的加快衰老是一个潜在的因素,与正常衰老和并发症不同.
研究的目的:
- 为了比较患有儿科发病性多发性硬化症 (POMS) 的儿童与年龄相匹配的健康对照组之间的表观遗传年龄.
- 调查多发性硬化是否导致儿科人口过早衰老.
- 验证年轻人队列中的发现,支持成年MS研究中的假设.
主要方法:
- 一项多中心病例控制研究分析了全血样本中的DNA甲基化数据.
- 用四种已建立的表观遗传时钟算法来计算表观遗传年龄.
- 多变量回归分析,调整为共变量,比较了POMS病例和对照之间的表观遗传年龄和年龄加速残留值 (AAR).
主要成果:
- 与对照组相比,患有POMS的参与者表现出更大的表观遗传年龄和AAR.
- 这种差异对于汉努姆和费诺时代的表观遗传钟来说具有统计学意义.
- 根据年龄,性别,BMI,吸烟和社会经济地位进行了调整.
结论:
- 在所有测试时钟中,患有POMS的儿童的表观遗传年龄始终更高.
- 汉纳姆时钟和芬诺时钟显示了统计学上显著的差异,表明POMS的加快衰老.
- 这些发现表明,在MS的早期过程中,即使在儿科患者中,也可能发生加速衰老.
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