延长青春还是延长更年期? 小心子的脚
Nanette F Santoro1, Sean D Lawley2, Mary D Sammel3
1Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO.
概括
努力延长卵巢功能可能会导致延长更年期的过渡. 历史数据表明,月经周期对妇女的健康并非必不可少,而且可能导致患病率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇女健康 妇女健康
- 长寿研究的研究.
背景情况:
- 质疑了每月排卵性月经周期对女性健康至关重要的假设.
- 经过数十年的月经周期会导致女性的不良健康后果.
研究的目的:
- 讨论延长人类卵巢功能寿命的潜在不良结果.
- 评估旨在延迟更年期的策略及其影响.
主要方法:
- 审查历史生殖模式和月经周期的后果.
- 检查绝经后荷尔蒙治疗的证据及其对寿命的益处.
- 使用卵巢卵泡枯竭的数学模型来预测更年期过渡时间.
主要成果:
- 从历史上看,女性由于怀孕和缺血而经历了长时间没有月经周期的月经周期.
- 每月的月经周期有助于在生殖年期间显著的发病率.
- 绝经后的激素替代疗法没有显示增加寿命;卵泡恢复可能会延长绝经.
结论:
- 延迟更年期的策略需要仔细考虑意外后果.
- 在更广泛的采用之前,治疗试验应该优先考虑那些最有可能受益的人.
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