在精神分裂症中皮质中线结构的预反射和反射异常
Maria Chiara Piani1, Martin Jandl2, Thomas Koenig2
1Translational Research Center, University Hospital of Psychiatry and Psychotherapy Bern UPD, Switzerland; Graduate School for Health Sciences, University of Bern, Switzerland.
这项研究揭示了精神分裂症谱系障碍 (SSD) 与自我障碍 (SDs) 相关的个体的独特大脑活动模式. 额头后带带皮质中的异常与反射前自我体验有关,而反射自我体验则涉及患者与对照者的不同神经网络.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 自我障碍 (SD) 是精神分裂谱系障碍 (SSD) 的核心特征,影响自我意识的预反射和反射方面.
- 了解SDs的神经支对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查SSD患者中预反射和反射自我体验的神经相关物.
- 使用功能磁共振成像 (fMRI) 在认知任务期间区分与SDs相关的大脑活动模式.
主要方法:
- 27名SSD患者和32名健康对照者 (HC) 接受了7次特斯拉fMRI扫描.
- 一个特征判断范式评估了自我参考和其他参考处理.
- 异常自我体验检查 (EASE) 尺度测量了SD的严重程度.
主要成果:
- 在反射前水平上,正面后带带皮层活动和SD严重程度之间的负相关性.
- 健康对照组显示前极皮质和前带皮质的激活,用于反射自我体验.
- 患有SSD的患者在反射自我体验期间在尾状核,前极皮质和语言区域表现出明显的激活.
结论:
- 额头后带带皮层的异常与SSD的预反射性自我障碍有关.
- 在SSD中,反思性自我体验涉及分析和更深层次的大脑网络的参与,与HC中观察到的整体感知过程相比.
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