在常量负荷动态任务上的表现疲劳性在中度重症帕金森病的女性中比健康衰老对照中更大
Avery Hinks1, Pardeep Khangura1, Elira Leake1
1Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.
概括
与健康人相比,患有帕金森病 (PD) 的人在持续的腿部运动中经历的表现疲劳不同. 这项研究揭示了肌肉疲劳和PD恢复的独特模式,为日常的身体挑战提供了洞察力.
科学领域:
- 神经学 神经学
- 运动生理学 运动生理学
- 生物医学工程 生物医学工程
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,经常伴随着自我报告的疲劳.
- 性能疲劳,持续努力期间肌肉强度或功率的下降,在PD中不明,特别是在日常生活中常见的同位素收缩期间.
研究的目的:
- 为了比较PD患者和健康衰老对照者在同位素膝盖延伸任务期间的表现疲劳和恢复.
- 为了研究神经肌肉对PD疲劳收缩的反应.
主要方法:
- 15名患有PD的女性和14名健康对照人使用动力计进行了重复的最大努力同位素膝盖延伸,直到峰值功率降低了40%.
- 性能疲劳性是通过重复到任务失败来衡量,在任务后10分钟评估神经肌肉恢复.
- 这些措施包括最大自愿收缩 (MVC) 扭矩,自愿激活,四头肌电动图 (EMG) 和扭矩.
主要成果:
- 尽管基线神经肌肉功能相似,但患有PD的个体完成的重复到失败的次数减少了~58%.
- 任务后,PD显示MVC扭矩,自愿激活和四头肌EMG的损伤较小,与对照组相比,扭矩损伤类似.
- 恢复动力学有所不同,PD显示MVC扭矩和四叉体EMG的恢复速度更快,而功率和扭矩扭矩恢复是相似的.
结论:
- 与健康对照组相比,异质性表现疲劳性在PD患者中表现出明显的特征.
- 这些发现为PD疲劳的身体表现提供了新的见解.
- 了解这些差异可以为疾病进展监测和管理策略提供信息.
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