通过破坏丸功能和当地的微环境,p-phenoxyphenol 损害了男性的生育能力
Xiaojuan Han1, Danni Jiang1, Qianni Li1
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong 250012, China; Shandong Key Laboratory of Reproductive Health and Birth Defects Prevention and Control, Ji'nan, Shandong 250012, China.
Ecotoxicology and environmental safety
|June 3, 2025
概括
暴露在p-phenoxyphenol (PhOP) 中会通过破坏丸结构和降低小鼠的精子运动性来损害男性生育能力. 这种内分泌干扰化学物质也会影响人类样本中的精子功能.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- p-phenoxyphenol (PhOP) 是一种具有已知的雌激素活性的工业化学物质.
- 它对男性生殖毒性的特定影响仍然在很大程度上未被描述.
- PhOP可以从各种消费和工业产品中释放出来.
研究的目的:
- 在小鼠模型中研究p-phenoxyphenol (PhOP) 的男性生殖毒性.
- 阐明PHOP诱导的生殖损伤背后的细胞和分子机制.
- 评估PhOP对人类精子运动性的影响.
主要方法:
- 在6周内,小鼠通过 gavage 暴露在不同剂量的 PhOP (3,30,100 mg/kg/d) 中.
- 在体外研究中,丸细胞系 (GC-2,TM3,TM4) 被PHOP (0-40μM) 暴露在24小时内.
- 在小鼠和人类精液样本中评估了精子运动性.
主要成果:
- 在小鼠中,PhOP暴露显著降低了精子的运动性和损坏了丸结构.
- 在小鼠丸中观察到细胞增殖的抑制,细胞亡的促进和高氧化应激.
- 在人类样本中,PhOP破坏了类固醇生成,破坏了血屏障,并降低了精子的运动性.
结论:
- p-氧 (PhOP) 通过对丸和精子的多方面的损害诱导男性生殖毒性.
- PhOP对哺乳动物构成生殖风险,强调需要进一步进行风险评估.
- 这些发现为 PhOP 暴露的生殖危害提供了新的见解.
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