在健康的马来西亚青春期前儿童中,骨质量,肌肉骨单位和骨周转标记
Kanimolli Arasu1, Winnie Chee Siew Swee1, Connie M Weaver2
1Division of Nutrition, Dietetics and Food Science, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.
Annals of pediatric endocrinology & metabolism
|June 3, 2025
概括
这项研究确定了马来西亚儿童的规范性骨质量和肌骨单位值. 研究结果强调,与其他亚洲人群相比,骨矿物质密度较低,强调需要量身定制的骨评估.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨健康研究 骨健康研究
- 人类生理学 人类生理学
背景情况:
- 准确的儿童骨评估需要对骨质量,骨周转标记 (BTMs) 和肌骨单位 (MBU) 进行人口特异性规范性数据.
- 现有的数据可能不能充分代表多样化的亚洲儿科人口.
研究的目的:
- 在健康的马来西亚青春期前儿童中描述骨矿物质密度 (BMD),骨矿物质含量 (BMC),BTM和MBU.
- 建立一个参考数据集,用于在这个人口中进行骨评估.
主要方法:
- 对243名9至11岁的马来西亚儿童进行了横截面研究.
- 双能X射线吸收计 (DXA) 测定全身和腰椎骨质量和骨质量.
- 血清BTM和完整的副甲状腺激素的生物化学测定.
主要成果:
- 大多数参与者 (97.5%) 的全身BMD (TBBMD) z-score高于-1 SD.
- 一个很小的百分比 (2.5%) 面临年龄低的TBBMD的风险.
- 马来西亚儿童的TBBMD比其他亚洲队伍中的同龄人低,尽管身体重量相似,但在BTM和MBU中观察到的性别特异性差异.
结论:
- 这项研究为马来西亚青少年前骨健康提供了重要的基于人口的数据集.
- 这些数据有助于在这个特定人群中准确地评估和监测骨.
- 这些发现强调了儿童骨发育的潜在种族或区域差异.
相关概念视频
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:17Hormones and Bone Tissue
3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
01:29Bone Formation by Intramembranous Ossification
9.9K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.9K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
01:09Changes in the Appendicular Skeleton with Age
3.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
01:31Essential Minerals for Bone Health
5.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K