艾滋病毒感染,抗逆转录病毒疗法和血管功能障碍:影响,机制和治疗方法
Shulin Wei1, Paul C Evans2, Hans Strijdom3
1Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Anhui Provincial Key Laboratory of Metabolic Health and Panvascular Diseases, Hefei 230001, China.
Pharmacological research
|June 3, 2025
概括
抗逆转录病毒疗法 (ART) 可以延长艾滋病毒感染者 (PLWH) 的寿命,但会增加心血管疾病 (CVD) 的风险. 艾滋病毒和ART可以导致内皮功能障碍,影响血管健康和恶化PLWH中的心血管疾病.
科学领域:
- 心血管科学 心血管科学
- 传染性疾病 传染性疾病
- 血管生物学 血管生物学
背景情况:
- 抗逆转录病毒疗法 (ART) 显著改善了艾滋病毒感染者 (PLWH) 的预期寿命.
- 尽管ART取得了成功,但PLWH中心血管疾病 (CVD) 发病率的增加令人担忧.
- 艾滋病毒感染本身和ART治疗有助于内皮功能障碍 (ED),这是心血管疾病发展的关键因素.
研究的目的:
- 审查当前对艾滋病毒感染和ART如何影响内皮功能的理解.
- 探索HIV相关的内皮功能障碍和心血管疾病背后的机制.
- 为开发更安全,个性化的艾滋病毒治疗策略提供框架.
主要方法:
- 对研究HIV和ART对内皮功能影响的临床研究和动物模型的审查.
- 检查内皮细胞 (EC) 功能障碍机制的体外研究的分析.
- 专注于高风险心血管疾病人群的ART诱导的血管功能障碍.
主要成果:
- 艾滋病毒感染通过病毒复制,蛋白质表达,慢性炎症和氧化应激诱导ED.
- ART可以导致EC激活,血管硬,血管扩张受损和内皮结构改变.
- 这些综合作用加剧了PLWH中心血管疾病的进展.
结论:
- 艾滋病毒内皮质学是复杂的,涉及病毒及其治疗.
- 由ART引起的血管功能障碍是一个关键问题,特别是在高心血管疾病风险的PLWH中.
- 需要进一步的研究,以指导更安全,长期的艾滋病毒管理和心血管疾病预防.
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