睡眠碎片化和睡眠阶段1和2与认知正常的老年人中的粉样β负担有关
Lauren K Hand1, Mickeal N Key2, Eric D Vidoni2
1Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Journal of sleep research
|June 3, 2025
概括
睡眠不足,包括更长的第一阶段和更短的第二阶段睡眠,与老年人中较高的粉样蛋白-β (Aβ) 负担有关. 这表明睡眠质量可能是早期的阿尔茨海默氏症.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 失眠是阿尔茨海默病 (AD) 的已知危险因素.
- 粉样β (Aβ) 水平的升高与失眠有关.
- 需要采取客观措施来证实睡眠与Aβ负担之间的联系.
研究的目的:
- 调查客观睡眠特征与Aβ负担之间的关联.
- 为了严格的评估,利用多睡眠学和正子发射断层扫描 (PET) 进行严格的评估.
主要方法:
- 对具有失眠症状的认知正常老年人 (60-85岁) 进行横截面研究.
- 进行了夜间多睡眠扫描和PET扫描.
- 皮尔森相关性和多变量回归分析了对大脑区域的Aβ SUVR的睡眠变量,控制年龄和APOE基因型.
主要成果:
- 较长的第1阶段睡眠与较高的全球皮层和中间前额叶皮层 (mPFC) Aβ相关.
- 睡眠开始后的觉醒增加与皮质,mPFC和前区域的Aβ水平较高相关.
- 较短的第二阶段睡眠与较高的后带带皮层 (PCC) Aβ相关.
- 与没有Aβ升高的个体相比,Aβ升高的个体表现出更长的第一阶段睡眠和更短的第二阶段睡眠.
结论:
- 较大的睡眠碎片化,较长的第一阶段睡眠和较短的第二阶段睡眠与认知正常的老年人中的Aβ负担增加有关.
- 睡眠质量差可能是Aβ积累的早期风险因素.
- 睡眠干预可以成为阿尔茨海默病预防策略的潜在目标.
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