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Updated: Mar 8, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
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Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

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抗原持久性和TLR刺激有助于诱导持久的HIV-1特异性中和抗体反应

Kenta Matsuda1, Mitra Harrison1, Eleanor Wettstein1

  • 1HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature communications
|June 3, 2025
PubMed
概括

开发一种有效的艾滋病毒疫苗是具有挑战性的,因为病毒的恩维糖蛋白不稳定性. 复制自然病毒感染的特征,特别是剂量和升级剂量,是改善HIV Env免疫性和诱导持久中和抗体的关键.

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