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Updated: Sep 19, 2025

Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
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一种人工智能发现的TNIK抑制剂用于异常性肺纤维化:一个随机的2a期试验

Zuojun Xu1, Feng Ren2, Ping Wang3

  • 1Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China. xuzj@hotmail.com.

Nature medicine
|June 3, 2025
PubMed
概括

人工智能生成的治疗异常性肺纤维化 (IPF) 的药物rentosertib在2a期试验中显示出有前途的安全性和有效性. 针对TNIK的药物改善了肺功能,这需要对这种渐进的肺病进行进一步的临床研究.

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A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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