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用BDNF作为评估过敏性鼻炎患者临床反应的生物标志物,这些患者接受过敏原特异性免疫治疗

Hongping Zhang¹, Yiran Zang¹, Xu Li²

¹Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, Shandong, China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|June 3, 2025

概括

血清脑源性神经营养因子 (BDNF) 水平在过敏性鼻炎 (AR) 患者中升高,与症状严重程度相关. 在皮下免疫疗法 (SCIT) 期间,BDNF水平下降表明治疗的有效性.

科学领域:

过敏和免疫学过敏和免疫学
神经科学是一个神经科学.
生物标志物研究生物标志物研究

背景情况:

过敏性鼻炎 (AR) 显著影响生活质量.
目前的治疗重点是症状管理,但需要治疗疗效的生物标志物.
大脑衍生神经营养因子 (BDNF) 涉及炎症和神经过程.

研究的目的:

在接受SCIT的AR患者中研究血清BDNF水平与临床/免疫学参数之间的相关性.
评估BDNF作为一个潜在的生物标志物来监测SCIT在3年的有效性.

主要方法:

在AR患者和健康对照中测量了血清BDNF水平,总IgE,特定IgE (d1,d2) 和临床参数.
在SCIT期间,在SCIT之前和每年3年进行一次测量.
分析了BDNF,临床得分 (鼻腔症状) 和外围参数 (乙酸蛋白) 之间的相关性.

主要成果:

与对照组相比,AR患者的血清BDNF水平显著更高.
升高的BDNF与增加的鼻腔症状严重程度和更高的乙氨基酸细胞数量相关.
在SCIT的3年期间,血清BDNF水平显示出显著的下降趋势,与症状改善相关.

结论:

血清BDNF水平与AR患者的临床严重程度有关.
在特定过敏原免疫疗法中,BDNF可以作为一个有价值的生物标志物来评估治疗反应和临床疗效.

关键词:

过敏原免疫疗法免疫疗法过敏性鼻炎是一种过敏性鼻炎.生物标志物生物标志物大脑衍生神经营养因子 (BDNF)评价评价评价

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