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Updated: Sep 19, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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BC12-3在多发性骨髓瘤上通过蛋白酶体抑制产生抗瘤作用

Huiying Li1, Geng Jia2, Naixin Zhang1

  • 1Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.

Medical oncology (Northwood, London, England)
|June 3, 2025
PubMed
概括

一种新的蛋白质酶体抑制剂BC12-3通过选择性抑制蛋白质酶体活性,显示出强大的抗多发性骨髓瘤 (MM) 活性. 这种化合物有效地抑制瘤生长并诱导亡,为MM治疗提供了一个有前途的新疗法策略.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.在BC12-3中使用.多发性骨髓瘤是一种多发性骨髓瘤.蛋白质酶体抑制剂 蛋白质酶体抑制剂

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