在横隔膜中可卡因和胺调节的转录的厌食和焦虑作用
Anjali Shankhatheertha1, Mikayla A Payant1, Jenny Phy-Lim1
1Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Journal of neuroendocrinology
|June 3, 2025
概括
可卡因和胺调控转录 (CART) 在侧隔膜中与黑色素缩激素 (MCH) 同释放时抑制食. 在男性中,CART还独立地诱导类似焦虑的行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经内分泌学神经内分泌学
背景情况:
- 可卡因和胺调节转录 (CART) 和黑色素缩激素 (MCH) 在向侧隔膜 (LS) 投射的下丘脑神经元中共同产生.
- MCH促进了食并减少了焦虑,而CART具有相反的效果,表明LS内部的复杂相互作用.
- 在LS中,CART和MCH之间的功能相互作用,特别是与食和焦虑有关的功能相互作用,仍然在很大程度上未被探索.
研究的目的:
- 调查CART和MCH对侧面隔膜食和焦虑类行为的独立和联合作用.
- 为了确定CART是否以性别特定的方式调节MCH驱动的食和焦虑.
主要方法:
- 在雄性和雌性野生型小鼠的侧面或中间LS植入双侧.
- 输注载体,CART55-102,MCH或CART+MCH进行了.
- 食物摄入量 (和高糖饮食) 和类似焦虑的行为 (开放场地测试) 被评估了4个小时.
主要成果:
- 单独的LS内CART输液并没有抑制养.
- 卡特输液减弱了MCH诱导的养,特别是当输入到侧面的LS时.
- 内部LS CART输液减少了男性在开放场中心的时间,但女性没有,这表明有焦虑效应.
结论:
- 在LS中存在MCH时,CART会引起厌食效应,这表明它在养调节中起着调节作用.
- 在雄性小鼠中,CART独立诱导类似焦虑的行为.
- 从下丘脑神经元中同时释放的CART和MCH可能会调节LS中食和焦虑的双相调节.
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