在多发性硬化症的性别肯定干预和预后
Nur Neyal1,2, Nabeela Nathoo1,3, Elizabeth J Cathcart-Rake4,5
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
概括
性别确认激素治疗可能会改变跨性别和性别多样性个体的多发性硬化症 (MS) 疾病过程. 与MS的跨性别男性相比,MS的跨性别女性可能会经历更渐进的疾病和残疾.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 性别确认激素治疗 (GAHT) 与多发性硬化症 (MS) 风险的潜在增加有关.
- 跨性别和性别多样性 (TGD) 个体的多发性硬化症病程尚不清楚.
- 这项研究调查了诊断为MS (TGD-MS) 的TGD个体的MS疾病过程.
研究的目的:
- 评估跨性别和性别多样性个体 (TGD-MS) 多发性硬化症 (MS) 的疾病过程.
- 为了比较MS的结果与MS的跨性别女性 (TW-MS) 和经历GAHT的MS的跨性别男性 (TM-MS).
主要方法:
- 对17个TGD-MS病例的回顾性分析.
- 专注于10名TGD-MS患者的GAHT,包括5名TW-MS和5名TM-MS.
- 评估症状/无症状疾病活动和渐进性MS (PMS) 发病情况.
主要成果:
- 患有多发性硬化症 (TW-MS) 的跨性别女性比患有多发性硬化症 (TM-MS) 的跨性别男性更年长,晚些时候出现多发性硬化症.
- 在四名TW-MS患者中,发生了渐进性MS (PMS),在三名患者中,GAHT先于PMS发作.
- 与TM-MS相比,在TW-MS中观察到更高的残疾.
结论:
- GAHT可能会改变多发性硬化症的病程,可能在TW-MS和TM-MS之间存在差异.
- 迫切需要进行更大规模的长期研究,以解决TGD人群中MS护理差异.
- 综合性GAHT史,及时管理和密切跟踪对TGD-MS至关重要.
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