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Updated: Sep 19, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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15种必需药物的物理和药物稳定性在寒冷和超寒冷环境中

Jason McMullan1, Christopher Droege, Thomas Blakeman

  • 1From the Department of Emergency Medicine (J.M.), University of Cincinnati College of Medicine; Department of Pharmacy Services (C.D., M.F.), UC Health, University of Cincinnati Medical Center; Division of Pharmacy Practice and Administration (C.D., M.F.), University of Cincinnati James L. Winkle College of Pharmacy; Department of Surgery, Division of General Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio (C.B., E.M.); and Cape Fox Federal Integrators (J.-M.F., M.S.), Chantilly, Virginia.

The journal of trauma and acute care surgery
|June 4, 2025
PubMed
概括

关键药物在暴露于极度寒冷时会降解或失效,例如深或冷解周期,影响其在恶劣环境中的稳定性和有效性.

关键词:
军事医学 军事医学药物的安全性 药物的安全性药物的稳定性 药物的稳定性

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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